August 13, 2013

Influence of Initial Treatment Modality on Long-Term Control of Chronic Idiopathic Urticaria

RESEARCH ARTICLE

Influence of Initial Treatment Modality on Long-Term Control of Chronic Idiopathic Urticaria

  • Sujeong Kim,
  •  
  • Seunghee Baek,
  •  
  • Bomi Shin,
  •  
  • Sun-young Yoon,
  •  
  • So Young Park,
  •  
  • Taehoon Lee,
  •  
  • Yoon Su Lee,
  •  
  • Yun-Jeong Bae,
  •  
  • Hyouk Soo Kwon,
  • You Sook Cho,
  •  
  • Hee-Bom Moon,
  •  
  • Tae-Bum Kim mail

Abstract

Background

Chronic idiopathic urticaria (CIU) is a common cutaneous disorder but the influence of initial treatment modality on long-term control is not known. The aim of this study was to evaluate clinical features, and the influence of initial treatment modality on long-term control.

Methods and Results

641 CIU patients were enrolled from the allergy clinic in a tertiary referral hospital. Disease duration, aggravating factors and treatment modality at each visit were evaluated. Times required to reach a controlled state were analyzed according to initial treatment modality, using Kaplan-Meier survival curves, the Cox proportional-hazards model, and propensity scores. Female to male ratio was 1.7: 1; mean age at onset was 40.5 years. The most common aggravating factors were food (33.5%), stress (31.5%) and fatigue (21.6%). Most patients (82.2%) used H1-antihistamines alone as initial treatment while 17% used a combination treatment with oral corticosteroids. There was no significant difference in the time taken to reach a controlled state between patients treated with single vs multiple H1-antihistamines or between those who received H1-antihistamine monotherapy vs. a combination therapy with oral corticosteroids.

Conclusion

The time required to control CIU is not reduced by use of multiple H1-antihistamines or oral corticosteroids in the initial treatment.

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